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Vitamin E Metabolites: Synthesis of [D 2 ]‐ and [D 3 ]‐γ‐CEHC
Author(s) -
Mazzini Francesco,
Galli Francesco,
Salvadori Piero
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600652
Subject(s) - chemistry , deuterium , hydroquinone , vitamin , organic chemistry , biochemistry , physics , quantum mechanics
Deuterated analogues of α‐ and γ‐CEHC, main urinary and plasma metabolites of vitamin E, can be traced and accurately determined quantitatively by MS in complex matrices. In that regard, here we report the first synthesis of rac ‐[D 3 ]‐γ‐CEHC together with a simple route to 7a,8a‐[D 2 ]‐γ‐CEHC through the set up of efficient procedures for the preparation of the corresponding deuterated hydroquinone building blocks. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)