Chemoenzymatic Synthesis of 5‐Thio‐ D ‐xylopyranose | Zendy

Charmantray Franck | Zendy; Dellis Philippe | Zendy; Hélaine Virgil | Zendy; Samreth Soth | Zendy; Hecquet Laurence | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Chemoenzymatic Synthesis of 5‐Thio‐ D ‐xylopyranose

Author(s) -

Charmantray Franck,

Dellis Philippe,

Hélaine Virgil,

Samreth Soth,

Hecquet Laurence

Publication year - 2006

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200600627

Subject(s) - ketose , thio , chemistry , aldolase a , synthon , transketolase , stereochemistry , stereospecificity , vetting , isomerization , glucose 6 phosphate isomerase , hydrogenolysis , enzyme , biochemistry , glycoside , aldose , catalysis , political science , law

5‐thio‐ D ‐xylopyranose, a synthon used for the preparation of drugs with antithrombotic activity, was synthesised by an enzymatic isomerisation from the corresponding ketose, 5‐thio‐ D ‐xylulofuranose, with glucose isomerase. This compound was obtained by two different chemoenzymatic routes, the key step being the stereospecific formation of a C–C bond, catalysed by transketolase or fructose‐1,6‐bisphosphate aldolase. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research