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Diastereoselective Synthesis of ‐Hydroxy Sulfoxides: Enzymatic and Biomimetic Approaches
Author(s) -
Colonna Stefano,
Pironti Vincenza,
Zambianchi Francesca,
Ottolina Gianluca,
Gaggero Nicoletta,
Celentano Giuseppe
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600624
Subject(s) - chemistry , cyclohexanone , bovine serum albumin , enzyme , monooxygenase , organic chemistry , enzyme catalysis , catalysis , combinatorial chemistry , biochemistry , cytochrome p450
Stereoselectivities of up to 98 % have been found in the enzymatic synthesis of β‐hydroxy sulfoxides catalyzed by cyclohexanone monooxygenase (CHMO). The diastereoselectivity of the “one‐pot” preparation of the title compounds in the presence of bovine serum albumin has also been investigated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)