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Asymmetric Hydrogenation of Pyridines: Enantioselective Synthesis of Nipecotic Acid Derivatives
Author(s) -
Lei Aiwen,
Chen Mao,
He Minsheng,
Zhang Xumu
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600558
Subject(s) - enantioselective synthesis , chemistry , nipecotic acid , asymmetric hydrogenation , homogeneous , catalysis , noyori asymmetric hydrogenation , pyridine , organic chemistry , transfer hydrogenation , biochemistry , physics , receptor , ruthenium , neurotransmitter , thermodynamics
An asymmetric hydrogenation process of 3‐substituted pyridine derivatives has been developed with the use of a Rh‐TangPhos complex as the catalyst. The whole process consists of an efficient partial hydrogenation of nicotinate and a subsequent highly enantioselective, Rh‐catalyzed, homogeneous hydrogenation. A series of chiral nipecotic acid derivatives have been synthesized. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)