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Suzuki–Miyaura Cross‐Coupling and Ring‐Closing Metathesis: A Strategic Combination for the Synthesis of Cyclophane Derivatives
Author(s) -
Kotha Sambasivarao,
Mandal Kalyaneswar
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600549
Subject(s) - chemistry , cyclophane , ring closing metathesis , metathesis , isomerization , stereochemistry , organic chemistry , catalysis , crystal structure , polymerization , polymer
The synthesis of cyclophane derivatives through a sequence involving Suzuki–Miyaura cross‐coupling between α,α′‐dibromo‐ m ‐xylene and arylboronic acid derivatives, alkenylation and ring‐closing metathesis has been achieved. One of the cyclophanes was obtained by tandem isomerization and metathesis. Significant magnetic anisotropic effects on the intra‐annular hydrogen atoms were observed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)