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Pd‐Catalysed Domino Arylation/CH Activation for the Synthesis of Acenaphthylenes
Author(s) -
Tietze Lutz F.,
Lotz Florian
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600428
Subject(s) - chemistry , domino , alkyne , moiety , palladium , aldehyde , aryl , combinatorial chemistry , organic chemistry , catalysis , medicinal chemistry , alkyl
The palladium‐catalysed domino cyclisation of the aryl bromides 4 , containing an alkyne and a bromonaphthyl moiety, leads to tetracycles of type 5 in good yields. The substrates 4 are easily accessible by addition of the corresponding lithiated alkynes 7 to the aldehyde 6 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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