Development of Synthetic Strategies for the Construction of Pyrido[4,3‐ d ]pyrimidine Libraries – the Discovery of a New Class of PDE‐4 Inhibitors | Zendy

Jang MiYeon | Zendy; De Jonghe Steven | Zendy; Gao LingJie | Zendy; Rozenski Jef | Zendy; Herdewijn Piet | Zendy

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Development of Synthetic Strategies for the Construction of Pyrido[4,3‐ d ]pyrimidine Libraries – the Discovery of a New Class of PDE‐4 Inhibitors

Author(s) -

Jang MiYeon,

De Jonghe Steven,

Gao LingJie,

Rozenski Jef,

Herdewijn Piet

Publication year - 2006

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200600339

Subject(s) - chemistry , pyrimidine , scaffold , combinatorial chemistry , stereochemistry , drug discovery , class (philosophy) , biochemistry , computer science , programming language , artificial intelligence

The synthesis of a pyrido[4,3‐ d ]pyrimidine library from 4,6‐diamino‐2‐bromonicotinamide and 4,6‐diaminonicotinamide is described. A systematic variation of the substituents at positions 2, 4, 5 and 7 of the pyrido[4,3‐ d ]pyrimidine scaffold was carried out, leading to a wide variety of structural analogues. This strategy led to the discovery of a new structural class of PDE‐4 inhibitors. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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