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One‐Pot Synthesis of (±)‐Crispine A and Its C‐Ring‐Substituted Analogs
Author(s) -
Meyer Nino,
Opatz Till
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600314
Subject(s) - chemistry , nitrile , ring (chemistry) , deprotonation , stereochemistry , medicinal chemistry , organic chemistry , ion
Abstract A straightforward access to crispine A and C‐ring‐substituted analogs by 1,4‐addition of a deprotonated α‐amino nitrile to α,β‐unsaturated carbonyl compounds is described. If the reduction step is omitted, substituted 5,6‐dihydropyrrolo[2,1‐ a ]isoquinolines can be obtained. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)