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Novel Synthetic Strategy Towards Taxol by Macrocyclization Reaction – Conformational Requirement of Ring A
Author(s) -
Canesi Sylvain,
Berthiaume Gilles,
Deslongchamps Pierre
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600284
Subject(s) - chemistry , ring (chemistry) , stereochemistry , combinatorial chemistry , organic chemistry
The synthesis of a completely substituted ring A of Taxol is reported and it is shown that the C 13 ‐OP group must have a β configuration to succeed in the formation of 12‐membered rings, a requisite for the construction of the B and C rings of Taxol by a macrocyclization step. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)