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A New Efficient Synthesis of Long‐Chain Di‐ and Triaminopolyols
Author(s) -
Coste Gérald,
GerberLemaire Sandrine
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600276
Subject(s) - chemistry , polyketide , amine gas treating , surface modification , combinatorial chemistry , chain (unit) , stereochemistry , enantioselective synthesis , long chain , organic chemistry , polymer science , catalysis , biosynthesis , physics , astronomy , enzyme
The asymmetric synthesis of long‐chain di‐ and triaminopolyols is reported. The developed methodology is based on the functionalization of 3,3′‐methylenebis{[6‐(benzyloxy)methoxy]cyclohept‐3‐en‐1‐ol} derivatives that allows theselective introduction of amine moieties at defined positions of polyketide fragments. The versatile strategy disclosed here requires few purification steps and may generate a large panel of stereoisomers. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)