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One‐Pot Synthesis of 3‐Substituted Isoquinolin‐1‐(2 H )‐ones and Fused Isoquinolin‐1‐(2 H )‐ones by S RN 1 Reactions in DMSO
Author(s) -
Guastavino Javier F.,
Barolo Silvia M.,
Rossi Roberto A.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600244
Subject(s) - chemistry , acetophenone , ketone , methyl ketone , medicinal chemistry , tetralone , organic chemistry , catalysis
3‐Substituted isoquinolin‐1‐(2 H )‐ones and fused isoquinolin‐1‐(2 H )‐ones have been obtained by the photostimulated S RN 1 reactions of 2‐iodobenzamide with the enolates of aromatic (acetophenone, 1‐(benzo[ d ][1,3]dioxol‐5‐yl)ethanone, 1‐ and 2‐naphthyl methyl ketones, and 2‐, 3‐, and 4‐acetylpyridine), aliphatic (1‐adamantyl methyl ketone), and cyclic ketones (1‐ and 2‐indanone, α‐ and β‐tetralone, and 1‐benzosuberone) in DMSO. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)