One‐Pot Synthesis of 3‐Substituted Isoquinolin‐1‐(2 H )‐ones and Fused Isoquinolin‐1‐(2 H )‐ones by S RN 1 Reactions in DMSO | Zendy

Guastavino Javier F. | Zendy; Barolo Silvia M. | Zendy; Rossi Roberto A. | Zendy

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One‐Pot Synthesis of 3‐Substituted Isoquinolin‐1‐(2 H )‐ones and Fused Isoquinolin‐1‐(2 H )‐ones by S RN 1 Reactions in DMSO

Author(s) -

Guastavino Javier F.,

Barolo Silvia M.,

Rossi Roberto A.

Publication year - 2006

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200600244

Subject(s) - chemistry , acetophenone , ketone , methyl ketone , medicinal chemistry , tetralone , organic chemistry , catalysis

3‐Substituted isoquinolin‐1‐(2 H )‐ones and fused isoquinolin‐1‐(2 H )‐ones have been obtained by the photostimulated S RN 1 reactions of 2‐iodobenzamide with the enolates of aromatic (acetophenone, 1‐(benzo[ d ][1,3]dioxol‐5‐yl)ethanone, 1‐ and 2‐naphthyl methyl ketones, and 2‐, 3‐, and 4‐acetylpyridine), aliphatic (1‐adamantyl methyl ketone), and cyclic ketones (1‐ and 2‐indanone, α‐ and β‐tetralone, and 1‐benzosuberone) in DMSO. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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