Diversity‐Oriented Synthesis of 2,5‐Disubstituted Tetrahydrofurans Based on a “Cyclization‐Hydrogenation‐Substitution” Strategy | Zendy

Freifeld Ilia | Zendy; Holtz Edith | Zendy; Dahmann Georg | Zendy; Langer Peter | Zendy

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Diversity‐Oriented Synthesis of 2,5‐Disubstituted Tetrahydrofurans Based on a “Cyclization‐Hydrogenation‐Substitution” Strategy

Author(s) -

Freifeld Ilia,

Holtz Edith,

Dahmann Georg,

Langer Peter

Publication year - 2006

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200600209

Subject(s) - chemistry , tetrahydrofuran , nucleophilic substitution , hydroxymethyl , substitution (logic) , organic chemistry , medicinal chemistry , solvent , computer science , programming language

A variety of (tetrahydrofuran‐2‐yl)acetates have been prepared based on hydrogenation and subsequent nucleophilic substitutions of 2‐alkylidene‐5‐(hydroxymethyl)tetrahydrofurans. The latter are readily available by cyclization of 1,3‐dicarbonyl dianions (“free dianions”) with epibromohydrin. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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