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Amino Acid Esters and Amides for Reductive Amination of Mucochloric Acid: Synthesis of Novel γ‐Lactams, Short Peptides and Antiseizure Agent Levetiracetam (Keppra ® )
Author(s) -
Das Sarma Koushik,
Zhang Ji,
Huang Yun,
Davidson James G.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600153
Subject(s) - chemistry , reductive amination , lactam , amination , levetiracetam , amino acid , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , catalysis , neuroscience , epilepsy , biology
A simple methodology utilizing mucochloric acid anddifferent α‐ and β‐amino acid esters, amides and shortpeptides for the synthesis of novel γ‐lactam and γ‐lactam‐based short peptides was developed. The synthesis of an antiseizure agent, Levetiracetam (Keppra ® ) was demonstrated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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