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Recent Developments in the Syntheses of the Epothilones and Related Analogues
Author(s) -
Watkins E. Blake,
Chittiboyina Amar G.,
Avery Mitchell A.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600149
Subject(s) - epothilones , chemistry , combinatorial chemistry , epothilone , stereochemistry
The macrocyclic class of antitumor compounds known as the epothilones has generated considerable interest since its discovery in 1993. Numerous total syntheses of this class of molecules have been published and countless structural analogues have been developed and tested for their abilities to promote tubulin polymerization. Several of these compounds are presently in clinical trials.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)