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Enantiodifferentiation of Aliphatic Ethers by the Dirhodium Method
Author(s) -
Díaz Gómez Edison,
Albert Dieter,
Duddeck Helmut,
Kozhushkov Sergei I.,
de Meijere Armin
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600137
Subject(s) - chemistry , enantiomer , nuclear magnetic resonance spectroscopy , ligand (biochemistry) , organic chemistry , stereochemistry , medicinal chemistry , receptor , biochemistry
The enantiomers of chiral aliphatic ethers can easily bedifferentiated by the dirhodium method, i.e. by 1 H and 13 C NMR spectroscopy in the presence of the chiral auxiliary Rh 2 [(+)‐MTPA] 4 . This is the first direct chiral recognitionby spectroscopic methods in this class of ligand compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)