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Synthesis of An Enantioenriched C 2 ‐Symmetric Molecule by a Chiral‐Base‐Mediated Kinetic Resolution of an (Arene)tricarbonylchromium(0) Complex
Author(s) -
Castaldi M. Paola,
Gibson Susan E.,
White Andrew J. P.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600018
Subject(s) - chemistry , kinetic resolution , trimethylsilyl , ether , base (topology) , stereochemistry , kinetic energy , molecule , derivative (finance) , resolution (logic) , enantioselective synthesis , computational chemistry , medicinal chemistry , organic chemistry , catalysis , mathematics , economics , mathematical analysis , physics , quantum mechanics , artificial intelligence , computer science , financial economics
Trimethylsilyl substituents have been used to control the conformational preferences of a 1,2‐disubstituted (arene)tricarbonylchromium(0) complex. The kinetic resolution of the mono‐methyl derivative (±)‐ 11 using a chiral base/iodomethane quench sequence led to the synthesis of the enantioenriched C 2 ‐symmetric bis‐ether (+)‐ 13 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)