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A Facile Stereoselective Synthesis of (2 E )‐3‐Silylallylic Alcohols by Hydromagnesiation of 1‐Aryl‐2‐silylacetylenes
Author(s) -
Cai Mingzhong,
Zhou Zhou,
Jiang Jianwen
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200501002
Subject(s) - chemistry , stereoselectivity , aryl , reagent , grignard reaction , diethyl ether , grignard reagent , ether , organic chemistry , alcohol , medicinal chemistry , catalysis , alkyl
Hydromagnesiation of 1‐aryl‐2‐silylacetylenes 1 in diethyl ether gave (1 E )‐2‐silylvinyl Grignard reagents 2 , which reacted with aldehydes or ketones 3 to afford stereoselectively (2 E )‐3‐silylallylic alcohols 4 in good to high yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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