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Metal‐Free Catalytic Nucleophilic Substitution of Propargylic Alcohols
Author(s) -
Sanz Roberto,
Martínez Alberto,
ÁlvarezGutiérrez Julia M.,
Rodríguez Félix
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500960
Subject(s) - chemistry , nucleophile , heteroatom , nucleophilic substitution , catalysis , organic chemistry , substitution reaction , carbon fibers , nucleophilic addition , combinatorial chemistry , medicinal chemistry , ring (chemistry) , materials science , composite number , composite material
Organic acids such as PTS efficiently catalyze direct nucleophilic substitutions of the hydroxy groups of propargylic alcohols with a large variety of carbon‐ and heteroatom‐centered nucleophiles. Reactions can be conducted under mild conditions and in air without the need for dried solvents. Reactions on multigram scales are also possible. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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