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Enantiospecific Synthesis of (+)‐Hyacinthacine A 2
Author(s) -
DewiWülfing Purnama,
Blechert Siegfried
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500914
Subject(s) - chemistry , dihydroxylation , sharpless asymmetric dihydroxylation , olefin metathesis , metathesis , stereochemistry , olefin fiber , enantioselective synthesis , total synthesis , combinatorial chemistry , organic chemistry , catalysis , polymer , polymerization
We report an efficient synthesis of (+)‐hyacinthacine A 2 in six steps from ( S )‐ N ‐Cbz‐vinylgylcine. The key strategies were the olefin cross metathesis (CM), Sharpless asymmetric dihydroxylation, and a sequential double reductive cyclization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)