Premium
The Domino Oxa‐Michael Addition–Aldol Reaction: Access to Variably Substituted Tetrahydroxanthenones
Author(s) -
Ohnemüller née Schmid Ulrike K.,
Nising Carl F.,
Nieger Martin,
Bräse Stefan
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500887
Subject(s) - aldol reaction , domino , chemistry , michael reaction , total synthesis , cascade reaction , tricyclic , stereochemistry , organic chemistry , catalysis
Tetrahydroxanthenones represent the core of many natural products, most of which exhibit interesting biological activities. In the course of our synthetic efforts towards the total synthesis of the secalonic acids, which contain two of these tricyclic units, we have investigated the influence of substituents on the one‐step domino oxa‐Michael addition–aldol reaction leading to tetrahydroxanthenones. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)