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Nebularic Acids and Nebularilactones, Novel Drimane Sesquiterpenoids from the Fungus Lepista nebularis
Author(s) -
Kemami Wangun Hilaire V.,
Dörfelt Heinrich,
Hertweck Christian
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500869
Subject(s) - chemistry , moiety , antifungal , stereochemistry , fungus , nuclear magnetic resonance spectroscopy , strain (injury) , mass spectrometry , organic chemistry , chromatography , microbiology and biotechnology , botany , medicine , biology
Four (nor‐)drimane sesquiterpenoids, nebularic acids A ( 1 ) and B ( 2 ) and nebularilactones A ( 3 ) and B ( 4 ), were isolated from a cultured Lepista nebularis strain by bioassay‐guided chromatography, and their structures were elucidated by mass spectrometry and NMR spectroscopy. Nebularic acid A ( 1 ) and in particular nebularic acid B ( 2 ), which features an α,β‐epoxy carboxylate moiety, show antifungal and antibacterial activities. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)