Nebularic Acids and Nebularilactones, Novel Drimane Sesquiterpenoids from the Fungus  Lepista nebularis | Zendy

Kemami Wangun Hilaire V. | Zendy; Dörfelt Heinrich | Zendy; Hertweck Christian | Zendy

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Nebularic Acids and Nebularilactones, Novel Drimane Sesquiterpenoids from the Fungus Lepista nebularis

Author(s) -

Kemami Wangun Hilaire V.,

Dörfelt Heinrich,

Hertweck Christian

Publication year - 2006

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200500869

Subject(s) - chemistry , moiety , antifungal , stereochemistry , fungus , nuclear magnetic resonance spectroscopy , strain (injury) , mass spectrometry , organic chemistry , chromatography , microbiology and biotechnology , botany , medicine , biology

Four (nor‐)drimane sesquiterpenoids, nebularic acids A ( 1 ) and B ( 2 ) and nebularilactones A ( 3 ) and B ( 4 ), were isolated from a cultured Lepista nebularis strain by bioassay‐guided chromatography, and their structures were elucidated by mass spectrometry and NMR spectroscopy. Nebularic acid A ( 1 ) and in particular nebularic acid B ( 2 ), which features an α,β‐epoxy carboxylate moiety, show antifungal and antibacterial activities. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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