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Synthesis and Characterization of PY2‐ and TPA‐Appended Diphenylglycoluril Receptors and Their Bis‐Cu I Complexes
Author(s) -
Sprakel Vera S. I.,
Elemans Johannes A. A. W.,
Feiters Martin C.,
Lucchese Baldo,
Karlin Kenneth D.,
Nolte Roeland J. M.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500865
Subject(s) - chemistry , amine gas treating , pyridine , tris , ligand (biochemistry) , copper , stereochemistry , metal , substrate (aquarium) , transition metal , combinatorial chemistry , receptor , polymer chemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , oceanography , geology
Abstract A number of metallohosts mimicking dinuclear copper oxygenases have been designed and synthesized. These metallohosts combine a substrate binding site, i.e. the diphenylglycoluril basket receptor, with two types of metal‐binding ligands, viz. tri‐coordinating bis(2‐ethylpyridine)amine (PY2) and tetra‐coordinating tris(2‐methylpyridine)amine (TPA). The preparation of the bis‐Cu I complexes of the ligand‐appended receptors and their characterization by NMR are reported. NMR spectroscopic data provide evidence for a dynamic inclusion behavior of some of the pyridine moieties in the receptor of both the metal‐free ligands and the Cu I complexes. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)