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A Ring‐Closing Metathesis Pathway to Fluorovinyl‐Containing Nitrogen Heterocyles
Author(s) -
De Matteis Valeria,
van Delft Floris L.,
Tiebes Jörg,
Rutjes Floris P. J. T.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500826
Subject(s) - chemistry , ring closing metathesis , metathesis , salt metathesis reaction , ring (chemistry) , olefin metathesis , closing (real estate) , fluoride , organic chemistry , stereochemistry , combinatorial chemistry , political science , law , polymerization , inorganic chemistry , polymer
The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring‐closing metathesis reaction involving fluoride‐substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)