Premium
A Ring‐Closing Metathesis Pathway to Fluorovinyl‐Containing Nitrogen Heterocyles
Author(s) -
De Matteis Valeria,
van Delft Floris L.,
Tiebes Jörg,
Rutjes Floris P. J. T.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500826
Subject(s) - chemistry , ring closing metathesis , metathesis , salt metathesis reaction , ring (chemistry) , olefin metathesis , closing (real estate) , fluoride , organic chemistry , stereochemistry , combinatorial chemistry , political science , law , polymerization , inorganic chemistry , polymer
The synthesis of highly functionalized fluorinated piperidines is described. The key step in this synthesis is a ring‐closing metathesis reaction involving fluoride‐substituted olefins, which leads to the corresponding cyclic vinyl fluorides. Several sequences to arrive at differently substituted piperidines have been evaluated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom