Premium
Solvent‐Free Carbon–Oxygen Bond Formation Catalysed by CeCl 3 ·7 H 2 O/NaI: Tetrahydropyranylation of Hydroxy Groups
Author(s) -
Bartoli Giuseppe,
Giovannini Riccardo,
Giuliani Arianna,
Marcantoni Enrico,
Massaccesi Massimo,
Melchiorre Paolo,
Paoletti Melissa,
Sambri Letizia
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500780
Subject(s) - chemistry , reagent , catalysis , phenols , solvent , carbon fibers , organic chemistry , reaction conditions , pyran , combinatorial chemistry , materials science , composite number , composite material
An efficient and highly chemoselective method fo the protection of free hydroxy compounds with 3,4‐dihydro‐2 H ‐pyran is reported. Since the deprotection of THP‐ethers occurs very readily at room temperature, the successful use of this type of protecting group depends only upon how readily it can be introduced. For this we have examined the tetrahydropyranylation of alcohols and phenols catalysed by the CeCl 3 · 7 H 2 O/NaI system surface under solvent‐free conditions. The reaction presents the advantage of being performable under extremely mild conditions by use of catalytic amounts of an interesting Lewis acidic system consisting of the CeCl 3 · 7 H 2 O/NaI catalyst combination, which can be easily separated from the reaction mixture. The advantages of this procedure, which utilizes cheap and “friendly” reagents, over the previously reported ones are discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)