Premium
The Influence of Ring Size on the Selectivity of Phosphorus Heterocycle Aminolysis in the Presence of Water or Alcohols – Case of 2‐Oxo‐ or 2‐Thioxo‐3‐sulfonyl‐1,3,2‐oxazaphosphorinanes
Author(s) -
Dujols Frédéric,
Mulliez Michel
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500743
Subject(s) - aminolysis , chemistry , sulfonyl , selectivity , ring (chemistry) , phosphorus , organic chemistry , ring size , medicinal chemistry , catalysis , alkyl
Seven phosphorus heterocycles 2 were synthesized in one step by condensing P IV dichlorides 3 with N ‐sulfonyl‐3‐aminopropanols 4 . In the presence of water, they react selectively with the less bulky amines. No change in selectivity of aminolysis was observed when using these six‐membered heterocycles 2 instead of their five‐membered analogs 1 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)