One‐Pot Addition/Reduction Procedure for the Synthesis of ‐Amino Alcohols from ‐Enamino Ketones | Zendy

Cimarelli Cristina | Zendy; Giuli Sandra | Zendy; Palmieri Gianni | Zendy

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One‐Pot Addition/Reduction Procedure for the Synthesis of ‐Amino Alcohols from ‐Enamino Ketones

Author(s) -

Cimarelli Cristina,

Giuli Sandra,

Palmieri Gianni

Publication year - 2006

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200500702

Subject(s) - chemistry , reagent , stereoselectivity , carbon atom , organic chemistry , carbon fibers , nuclear magnetic resonance spectroscopy , combinatorial chemistry , catalysis , alkyl , materials science , composite number , composite material

γ‐Amino alcohols 3 have been synthesized by the addition of organolithium reagents to β‐enamino ketones 1 followed by one‐pot reduction with sodium triacetoxyborohydride. The method allows the stereoselective synthesis of γ‐amino alcohols in which the hydroxy group is bonded to a fully substituted carbon atom. The relative configuration of the chiral product was determined by 1 H NMR spectroscopy. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

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