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Efficient Suzuki–Miyaura Coupling Reactions between Lithium Alkynyltrimethylborates and Aryl Chlorides
Author(s) -
Hernández Torres Gloria,
Choppin Sabine,
Colobert Françoise
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500697
Subject(s) - chemistry , aryl , steric effects , lithium (medication) , alkynylation , salt (chemistry) , coupling reaction , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , medicine , alkyl , endocrinology
The Pd‐catalysed alkynylation of alkynylboronic esters (generated in situ) with various aryl chlorides in the presence of Pd 2 (dba) 3 , the sterically hindered dihydroimidazolium salt 4 as the precatalyst and CsF is reported. Under these conditions, electron‐poor and electron‐rich aryl chlorides undergo efficient cross‐coupling reactions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)