A New Modular and Practical Methodology for the Synthesis of 4‐ or 3‐Substituted Phenyl C‐Nucleosides | Zendy

Hocek Michal | Zendy; Pohl Radek | Zendy; Klepetářová Blanka | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A New Modular and Practical Methodology for the Synthesis of 4‐ or 3‐Substituted Phenyl C‐Nucleosides

Author(s) -

Hocek Michal,

Pohl Radek,

Klepetářová Blanka

Publication year - 2005

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200500607

Subject(s) - chemistry , epimer , nucleoside , combinatorial chemistry , modular design , coupling reaction , nucleic acid , stereochemistry , organic chemistry , catalysis , biochemistry , computer science , operating system

A novel efficient and practical approach to the synthesis of 4‐ or 3‐substituted phenyl C‐nucleosides has been developed. It consists in coupling of protected halogenose 1 with bromophenylmagnesium bromides followed by acid mediated epimerization to prepare 4‐ or 3‐bromophenyl C‐nucleoside intermediates. Their Pd‐catalyzed cross‐coupling reactions with diverse organometallics followed by deprotection afforded the title nucleoside analogues. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research