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Synthesis and Functionalisation of 2,3‐Diheterocycle‐Substituted Aziridines
Author(s) -
Troisi Luigino,
Granito Catia,
Carlucci Claudia,
Bona Fabio,
Florio Saverio
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500570
Subject(s) - chemistry , electrophile , coupling reaction , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis
Polyfunctionalyzed aziridines each containing two heterocyclic moieties were prepared by Darzens reactions and the corresponding aziridinyl anions, generated by treatment with strong bases, were investigated. Coupling reaction with electrophiles allowed study of the configurational stability, highlighting the different stabilising effects of the heterocyclic substituents. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)