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Simple 1,2‐Diamine Ligands for Asymmetric Addition of Aryllithium Reagents to Imines
Author(s) -
Cabello Noemi,
Kizirian JeanClaude,
Gille Ségolène,
Alexakis Alexandre,
Bernardinelli Gérald,
Pinchard Laurent,
Caille JeanClaude
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500447
Subject(s) - chemistry , enantioselective synthesis , reagent , enantiomer , diamine , enantiomeric excess , combinatorial chemistry , organic chemistry , catalysis
Enantioselective addition of various aryllithium reagents to aromatic imines was catalyzed (20 mol‐%) by readily accessible 1,2‐diamines to afford a wide range of protected diarylmethylamines in up to 94 % enantiomeric excess. Furthermore, the absolute configuration of these arylation products was determined by using X‐ray crystallography. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)