z-logo
Premium
Amination with Oximes
Author(s) -
Narasaka Koichi,
Kitamura Mitsuru
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500389
Subject(s) - chemistry , intramolecular force , amination , oxime , medicinal chemistry , aryl , nucleophilic substitution , reagent , heck reaction , organic chemistry , palladium , catalysis , alkyl
The S N 2 reaction has been well recognized not to occur at sp 2 carbons, while such an S N 2‐type substitution reaction was found to proceed readily at the sp 2 nitrogen of oximes. Ab initio MP2 calculations show that the activation energy of the nucleophilic substitution at sp 2 nitrogen is almost same as that of the Beckmann rearrangement. By the intramolecular S N 2‐type reaction at the oxime nitrogen, various aza‐arenes and cyclic imines, such as quinolines, aza‐spiro compounds, and dihydropyrroles, can be synthesized. Intermolecular substitution of oximes with organometallic reagents also proceeds, and electrophilic amination of Grignard reagents is accomplished by the use of 4,4,5,5‐tetramethyl‐1,3‐dioxolan‐2‐one O ‐(phenylsulfonyl)oxime. Anion radicals generated by one‐electron reduction of oxime derivatives act as iminyl radical equivalents. That is, the intramolecular C–N bond formation of γ,δ‐unsaturated or β‐aryl oximes is induced by a single electron transfer to give various pyrroles, quinolines, and carbolines, in which phenols, hydroquinones, or copper reagents can be used as electron donors. A photo‐induced radical process is also applied to the transformation of γ,δ‐unsaturated oximes to dihydropyrroles. Oxidative addition of oximes to palladium(0) complexes generates alkylideneaminopalladium( II ) species, which are utilized as key intermediates in carbon–nitrogen bond formation. Various aza‐heterocycles, including pyrroles, pyridines, isoquinolines, spiroimines, and aza‐azulenes, are synthesized from O ‐(pentafluorobenzoyl)oximes having olefinic moieties via the intramolecular Heck‐type reaction (amino‐Heck reaction) by treatment with a catalytic amount of a Pd 0 complex. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here