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An Efficient Chemoenzymatic Synthesis of the Bactericide Lapyrium Chloride
Author(s) -
Rustoy Eduardo M.,
Baldessari Alicia
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500388
Subject(s) - chemistry , chloroacetic acid , chloride , yield (engineering) , broad spectrum , organic chemistry , antimicrobial , reaction conditions , combinatorial chemistry , catalysis , materials science , metallurgy
An efficient route for large‐scale preparation of lapyrium chloride, a broad‐spectrum antimicrobial surfactant, was developed from chloroacetic acid in four steps, three of them enzymatic. Due to the chemoselective behavior of the biocatalysts, lapyrium chloride was obtained in a high degree of purity and yield, from mild reaction conditions and following a low environmental impact methodology. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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