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Xyloketal F: A Strong L ‐Calcium Channel Blocker from the Mangrove Fungus Xylaria sp . (#2508) from the South China Sea Coast
Author(s) -
Wu Xiong Yu,
Liu Xiao Hong,
Lin Yong Cheng,
Luo Jing Hui,
She Zhi Gang,
Houjin Li,
Chan Wing Lai,
Antus Sándor,
Kurtan Tibor,
Elsässer Brigitta,
Krohn Karsten
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500326
Subject(s) - mangrove , chemistry , metabolite , fungus , stereochemistry , calcium channel , calcium , blocking (statistics) , botany , organic chemistry , biochemistry , ecology , biology , statistics , mathematics
Xyloketal F ( 1 ), an unusual metabolite with strong L ‐calcium channel blocking activity, was isolated from the mangrove endophytic fungus Xylaria sp. (#2508) collected at the South China Sea coast. Its structure was elucidated by spectral and single‐crystal X‐ray diffraction analysis. The absolute configuration of 1 was determined by the method of quantum‐mechanical calculation of CD spectra. Compound 1 was also synthesized by condensation of xyloketal B with formaldehyde. The L ‐calcium channel blocking activities of xyloketals B, A, and F were determined, and at the same concentration (0.03 μmol/L), the inhibiting rates were 12.05 %, 21.47 %, and 50.33 % respectively. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)