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New Method for the General Synthesis of [1,2,4]Triazolo[1,5‐ a ]pyridines
Author(s) -
Huntsman Elliott,
Balsells Jaume
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500247
Subject(s) - chemistry , trifluoroacetic anhydride , pyridine , aminopyridines , ring (chemistry) , medicinal chemistry , trifluoroacetic acid , organic chemistry
[1,2,4]Triazolo[1,5‐ a ]pyridines without substituents on the 2‐position have been prepared from 2‐aminopyridines by cyclization of N ‐(pyrid‐2‐yl)formamidoximes with trifluoroacetic anhydride. Triazoles substituted at any position on the pyridine ring may be prepared in good yields and under mild reaction conditions. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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