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High‐Yielding Microwave‐Assisted Synthesis of Triazole‐Linked Glycodendrimers by Copper‐Catalyzed [3+2] Cycloaddition
Author(s) -
Joosten John A. F.,
Tholen Niels T. H.,
Ait El Maate Fatna,
Brouwer Arwin J.,
van Esse G. Wilma,
Rijkers Dirk T. S.,
Liskamp Rob M. J.,
Pieters Roland J.
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500216
Subject(s) - chemistry , cycloaddition , triazole , catalysis , microwave irradiation , copper , click chemistry , combinatorial chemistry , stereochemistry , organic chemistry , polymer chemistry
Abstract A facile and high‐yielding synthesis of multivalent 1,4‐disubstituted 1,2,3‐triazole‐linked glycodendrimers is described. Azido carbohydrates are linked by a Cu I ‐catalyzed [3+2] cycloaddition reaction to dendritic acetylenes using microwave irradiation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)