Conformational Study of GPI Anchors: the Common Oligosaccharide GPI Anchor Backbone | Zendy

Chevalier Franck | Zendy; LopezPrados Javier | Zendy; Perez Serge | Zendy; MartínLomas Manuel | Zendy; Nieto Pedro M. | Zendy

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Conformational Study of GPI Anchors: the Common Oligosaccharide GPI Anchor Backbone

Author(s) -

Chevalier Franck,

LopezPrados Javier,

Perez Serge,

MartínLomas Manuel,

Nieto Pedro M.

Publication year - 2005

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200500171

Subject(s) - chemistry , glycosidic bond , intramolecular force , oligosaccharide , cleavage (geology) , molecule , hydrogen bond , stereochemistry , nuclear magnetic resonance spectroscopy , molecular dynamics , computational chemistry , biochemistry , organic chemistry , fracture (geology) , enzyme , geotechnical engineering , engineering

The solution three‐dimensional structure of pseudopentasaccharide 6 , which constitutes the product from the GPI‐PLD cleavage of a GPI anchor, has been studied using a protocol which involves a systematic search of the conformational space around the glycosidic linkages, a thorough molecular dynamics study with explicit water molecules and a full NMR analysis study of intramolecular hydrogen bonding in solution. The results indicate that 6 exists in an extended conformation with a considerable flexibility compatible with a hinge‐like conformational motion. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

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