Convenient Synthesis of Difluoromethyl Alcohols from Both Enolizable and Non‐Enolizable Carbonyl Compounds with Difluoromethyl Phenyl Sulfone | Zendy

Surya Prakash G. K. | Zendy; Hu Jinbo | Zendy; Wang Ying | Zendy; Olah George A. | Zendy

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Convenient Synthesis of Difluoromethyl Alcohols from Both Enolizable and Non‐Enolizable Carbonyl Compounds with Difluoromethyl Phenyl Sulfone

Author(s) -

Surya Prakash G. K.,

Hu Jinbo,

Wang Ying,

Olah George A.

Publication year - 2005

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200500101

Subject(s) - chemistry , sulfone , nucleophile , nucleophilic addition , medicinal chemistry , organic chemistry , catalysis

A general and efficient nucleophilic difluoromethylation of carbonyl compounds (both enolizable and non‐enolizable aldehydes and ketones) has been achieved by using a nucleophilic (phenylsulfonyl)difluoromethylation‐reductive desulfonylation strategy. Difluoromethyl phenyl sulfone acts as a difluoromethyl anion (“CF 2 H – ”) equivalent. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

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