Premium
Convenient Synthesis of Difluoromethyl Alcohols from Both Enolizable and Non‐Enolizable Carbonyl Compounds with Difluoromethyl Phenyl Sulfone
Author(s) -
Surya Prakash G. K.,
Hu Jinbo,
Wang Ying,
Olah George A.
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200500101
Subject(s) - chemistry , sulfone , nucleophile , nucleophilic addition , medicinal chemistry , organic chemistry , catalysis
A general and efficient nucleophilic difluoromethylation of carbonyl compounds (both enolizable and non‐enolizable aldehydes and ketones) has been achieved by using a nucleophilic (phenylsulfonyl)difluoromethylation‐reductive desulfonylation strategy. Difluoromethyl phenyl sulfone acts as a difluoromethyl anion (“CF 2 H – ”) equivalent. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)