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Cover Picture: Synthesis and Biological Evaluation of Macrosphelide Cores (Eur. J. Org. Chem. 19/2004)
Author(s) -
Ishihara Kentaro,
Kawaguchi Takanori,
Matsuya Yuji,
Sakurai Hiroaki,
Saiki Ikuo,
Nemoto Hideo
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200490038
Subject(s) - chemistry , allylic rearrangement , cover (algebra) , stereochemistry , ring (chemistry) , skeleton (computer programming) , organic chemistry , catalysis , mechanical engineering , engineering , computer science , programming language
Abstract The cover picture shows the structures of the bioactive natural macrolide, macrosphelide A (third structure from left) and its artificial analogues. The other structures exhibit different oxidation states at the allylic positions on the common 16‐membered ring skeleton. The antitumor activity increases from left to right. This image reflects the importance of the oxygen functionalities for the bioactivity of naturally occurring macrosphelides, as discussed in the article by H. Nemoto et al. on p. 3973 ff.