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Cover Picture: Chemical Synthesis of GPIs and GPI‐Anchored Glycopeptides (Eur. J. Org. Chem. 17/2004)
Author(s) -
Guo Zhongwu,
Bishop Lee
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200490034
Subject(s) - chemistry , glycopeptide , membrane , glycoprotein , membrane protein , eukaryotic cell , cell , cell membrane , biochemistry , lipid bilayer , stereochemistry , antibiotics
The cover picture shows a glycosylphosphatidylinositol(GPI‐)anchored protein that is associated with the cell membrane. The insertion of the long lipid chains of GPIs into the membrane bilayers anchors numerous proteins and glycoproteins onto cell surfaces. GPI anchoring is ubiquitous and plays a critical role in the eukaryotic world. The chemical synthesis of some GPIs and GPI‐linked peptides and glycopeptides is summarized in detail in the Microreview by Z. Guo and L. Bishop on p. 3585 ff.