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Cobalt‐Catalyzed Vinylation of Functionalized Aryl Halides with Vinyl Acetates
Author(s) -
Amatore Muriel,
Gosmini Corinne,
Périchon Jacques
Publication year - 2005
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400897
Subject(s) - chemistry , halide , aryl , cobalt , styrene , catalysis , vinyl bromide , bromide , organic chemistry , coupling reaction , polymer chemistry , medicinal chemistry , combinatorial chemistry , alkyl , copolymer , polymer
A new method for the preparation of styrene derivatives is described on the basis of the activation of aryl halides by low‐valent cobalt species. A combination of Co II bromide and 2,2′‐bipyridine is suitable as catalyst for the cross‐coupling reaction of a wide range of aromatic halides (X = Cl, Br, I), mostly bearing sensitive moieties, with vinyl acetates. These reactions proceed under mild conditions in the presence of the appropriate reducing agent to afford α‐substituted styrene compounds in satisfactory to high yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)