An Efficient Synthesis of Novel α‐Aminophosphonates Based on a Mannich‐Type Reaction | Zendy

Risch Nikolaus | Zendy; Piper Stefan | Zendy; Winter Andreas | Zendy; LefarthRisse Annette | Zendy

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An Efficient Synthesis of Novel α‐Aminophosphonates Based on a Mannich‐Type Reaction

Author(s) -

Risch Nikolaus,

Piper Stefan,

Winter Andreas,

LefarthRisse Annette

Publication year - 2005

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200400618

Subject(s) - chemistry , iminium , phosphonate , mannich reaction , nucleophile , salt (chemistry) , scope (computer science) , organic chemistry , combinatorial chemistry , catalysis , computer science , programming language

Phosphonate‐substituted iminium salt 2 was used in Mannich reactions with various nucleophiles to obtain novel α‐aminophosphonates. This straightforward and efficient methodology has a broad scope and provides highly functionalized Mannich bases ( 4 and 8 ). Furthermore, vinylic, aromatic and homoallylic α‐aminophosphonates ( 5 , 10 and 12 ) were synthesized in good yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)

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