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Synthesis of the First Chiral, Functionalised‐Bridged Resorcinarenes in Asymmetric Catalysis: Evidence for Intracavity Asymmetric Catalysis
Author(s) -
Arnott Gareth,
Heaney Harry,
Hunter Roger,
Page Philip C. B.
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400615
Subject(s) - chemistry , enantioselective synthesis , diethylzinc , catalysis , benzaldehyde , organic chemistry , organocatalysis , combinatorial chemistry
Methodology is presented for synthesis of the first examples of chiral, bridged resorcinarenes with functionality in the bridge as possible sites for intracavity asymmetric catalysis. A preliminary study comparing unfunctionalised with functionalised lines using the enantioselective addition of diethylzinc to benzaldehyde as a probe reaction, provides compelling evidence for intracavity catalysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)