Approaches to the Preparation of 4‐Benzyloxy‐2‐(α,α,α‐D 3 )methylphenol, a Building Block for Labeled δ‐Tocopherol, and a New Synthesis of  R , R , R ‐5‐D 3 ‐α‐Tocopherol | Zendy

Mazzini Francesco | Zendy; Mandoli Alessandro | Zendy; Salvadori Piero | Zendy; Netscher Thomas | Zendy; Rosenau Thomas | Zendy

Premium

Approaches to the Preparation of 4‐Benzyloxy‐2‐(α,α,α‐D 3 )methylphenol, a Building Block for Labeled δ‐Tocopherol, and a New Synthesis of R , R , R ‐5‐D 3 ‐α‐Tocopherol

Author(s) -

Mazzini Francesco,

Mandoli Alessandro,

Salvadori Piero,

Netscher Thomas,

Rosenau Thomas

Publication year - 2004

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200400535

Subject(s) - chemistry , tocopherol , block (permutation group theory) , phenol , combinatorial chemistry , stereochemistry , organic chemistry , antioxidant , combinatorics , vitamin e , mathematics

Different routes are described for the synthesis of 4‐benzyloxy‐2‐D 3 ‐phenol, a key building block in the preparation of D 3 ‐δ‐tocopherol. Conditions for the improvement of Minami’s reduction are also given, allowing a straightforward route to the title compound and a new synthesis of R , R , R ‐5‐D 3 ‐α‐tocopherol in good yields, starting from widely available R , R , R ‐α‐tocopherol. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research