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Intramolecular Ritter Reactions of 2‐(2‐Cyanoethyl)tetrahydrocyclopenta[ b ]indole and ‐carbazole Derivatives
Author(s) -
Maertens Faye,
Van den Bogaert An ,
Compernolle Frans,
Hoornaert Georges J.
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400409
Subject(s) - chemistry , indole test , ritter reaction , carbazole , intramolecular force , stereochemistry , intramolecular reaction , medicinal chemistry , organic chemistry , catalysis
Intramolecular Ritter reactions of 2‐(2‐cyanoethyl)tetrahydrocyclopenta[ b ]indole and ‐carbazole derivatives, prepared by a sequence of two different α‐substitutions and Grignard reactions of the indole‐based ketones 4‐methyl‐1,4‐dihydrocyclopenta[ b ]indol‐3(2 H )‐one and 9‐methyl‐2,3,4,9‐tetrahydro‐1 H ‐carbazol‐1‐one, were used as key steps in the construction of various tetracyclic lactam compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)