Synthesis of (ϵ‐ 13 C‐,ϵ‐ 15 N)‐Enriched  L ‐Lysine − Establishing Schemes for the Preparation of All Possible  13 C and  15 N Isotopomers of  L ‐Lysine,  L ‐Ornithine, and  L ‐Proline | Zendy

Siebum Arjan H. G. | Zendy; Tsang Robert K. F. | Zendy; Steen Rob van der | Zendy; Raap Jan | Zendy; Lugtenburg Johan | Zendy

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Synthesis of (ϵ‐ 13 C‐,ϵ‐ 15 N)‐Enriched L ‐Lysine − Establishing Schemes for the Preparation of All Possible 13 C and 15 N Isotopomers of L ‐Lysine, L ‐Ornithine, and L ‐Proline

Author(s) -

Siebum Arjan H. G.,

Tsang Robert K. F.,

Steen Rob van der,

Raap Jan,

Lugtenburg Johan

Publication year - 2004

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200400370

Subject(s) - chemistry , lysine , amino acid , isotopomers , ornithine , stereochemistry , arginine , molecule , organic chemistry , biochemistry

In this paper we describe a simple synthetic strategy that, with the right rational adaptation, gives direct access to any 13 C/ 15 N isotopomer of L ‐glutamate, L ‐ornithine, L ‐proline, L ‐lysine, and L ‐α amino adipic acid. This strategy also allows access to nonproteinogenic amino acids like L ‐citrulline in high yields and optical purity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

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