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Synthesis of (ϵ‐ 13 C‐,ϵ‐ 15 N)‐Enriched L ‐Lysine − Establishing Schemes for the Preparation of All Possible 13 C and 15 N Isotopomers of L ‐Lysine, L ‐Ornithine, and L ‐Proline
Author(s) -
Siebum Arjan H. G.,
Tsang Robert K. F.,
Steen Rob van der,
Raap Jan,
Lugtenburg Johan
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400370
Subject(s) - chemistry , lysine , amino acid , isotopomers , ornithine , stereochemistry , arginine , molecule , organic chemistry , biochemistry
In this paper we describe a simple synthetic strategy that, with the right rational adaptation, gives direct access to any 13 C/ 15 N isotopomer of L ‐glutamate, L ‐ornithine, L ‐proline, L ‐lysine, and L ‐α amino adipic acid. This strategy also allows access to nonproteinogenic amino acids like L ‐citrulline in high yields and optical purity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)