Premium
Synthesis of two Conformationally Restricted Piperazine Scaffolds for Combinatorial Chemistry
Author(s) -
Opatz Till
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400358
Subject(s) - chemistry , piperazine , combinatorial chemistry , molecule , stereochemistry , combinatorial synthesis , solid phase synthesis , organic chemistry , biochemistry , peptide
Piperazines are widely used as central elements in the construction of bioactive molecules. Herein, the short synthesis of two chiral 2,6‐bridged piperazines possessing orthogonally stable protecting groups from readily available starting materials is described. It is suggested that these molecules may be used as conformationally restricted scaffolds for the combinatorial synthesis of drug‐like compounds. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)