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Synthesis of Substituted Azepino[3,4‐ b ]indole‐1,5‐diones
Author(s) -
Perron Julien,
Joseph Benoît,
Mérour JeanYves
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400348
Subject(s) - chemistry , indole test , moiety , ethylene glycol , chloride , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry
Cyclic β‐amino esters 4 , obtained from lactams, were condensed with indole‐2‐carbonyl chloride to afford the corresponding amides. Similarly, unusual conditions led to cyclisation at the 3‐position of the indole moiety in the presence of p TSA and ethylene glycol to afford previously unknown pentacyclic derivatives 12 and 15 . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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