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Synthesis and Biological Evaluation of Macrosphelide Cores
Author(s) -
Ishihara Kentaro,
Kawaguchi Takanori,
Matsuya Yuji,
Sakurai Hiroaki,
Saiki Ikuo,
Nemoto Hideo
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400338
Subject(s) - chemistry , core (optical fiber) , biological activity , stereochemistry , total synthesis , combinatorial chemistry , biochemistry , in vitro , materials science , composite material
The simplified 16‐membered core structures of macrosphelides were synthesized in high overall yields starting from methyl (+)‐ or (−)‐3‐hydroxybutyrate as the sole chiral source. The antiproliferative activities of these macrosphelide cores against murine colon 26‐L5 adenocarcinoma cells were examined, and the results suggest that the oxygen functional groups found in the natural products are essential for their bioactivities. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)