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Stereo‐ and Regiocontrol in the Formation of Lactams by Rhodium‐Carbenoid C−H Insertion of α‐Diazoacetamides
Author(s) -
Gois Pedro M. P.,
Afonso Carlos A. M.
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400237
Subject(s) - carbenoid , chemistry , intramolecular force , rhodium , insertion reaction , stereochemistry , lactam , combinatorial chemistry , catalysis , organic chemistry
The dirhodium( II )‐catalysed intramolecular C−H insertion reaction of α‐diazoacetamides is a powerful methodology for the preparation of highly valuable heterocyclic compounds such as lactams. In this Microreview we present lactam formation by intramolecular C−H insertion of α‐diazoacetamides, focusing on the effects that have a profound impact on the reaction pathway. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)