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A Polymer‐Supported Phosphoramide as a Lewis‐Base Catalyst for the Catalytic Aldol Reaction
Author(s) -
Flowers Robert A.,
Xu Xin,
Timmons Cody,
Li Guigen
Publication year - 2004
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200400228
Subject(s) - chemistry , aldol reaction , catalysis , enol , lewis acids and bases , stereoselectivity , organic chemistry , lewis acid catalysis , base (topology) , polymer , mathematical analysis , mathematics
The aldol reactions between trichlorosilyl enol ethers and aldehydes were catalyzed by an environmentally benign polymer‐supported phosphoramide organocatalyst. Eight examples are reported with moderate to good chemical yields and stereoselectivity. Significant rate enhancements were observed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)